Hepatoprotective potential of ethanolic extract of pandanus. The protective action of the aqueous extract of auricularia. Amelioration of paracetamolinduced hepatotoxicity in rat by. Hepatotoxicity was induced in wistar rats by oral administration of paracetamol 640 mgkg suspended in 1% carboxy methyl cellulose, once during the 16 days treatment period. In conclusion, coadministration of paracetamol with inhibitors of cytochrome p450 prevented the development of paracetamol induced hepatotoxicity in rats, and this calls for researchfor enzyme inhibitors that may be of therapeutic value. G andresearchdepartment ofbiochemistry,jayacollege arts science, thiruninravur 602 024.
Paracetamolinduced hepatotoxicity in spraguedawley rat, nat. Paracetamol induced experimental liver damage in case of paracetamol induced hepatotoxicity, the rats were divided into 5 groups of 6 rats each. Hepatotoxicity from hepatic toxicity implies chemicaldriven liver damage. The biochemical measurements liver functions and markers of oxidative stress were assayed. Paracetamol induced hepatotoxicity pubmed central pmc. Hepatoprotective activity of nilgirianthus ciliatus nees. The present study was conducted to evaluate the hepatoprotective activity of ethyl acetate extract of aerial parts of launaea intybacea are evaluated in paracetamolinduced hepatotoxicity in albino rats. The analgesic acetaminophen causes a potentially fatal, hepatic centrilobular necrosis when taken in overdose. Materials and methods plant material fresh seeds of the plant sesamum indicum linn. Effect of rutin on paracetamolinduced hepatotoxicity control serum values of ast and alt in rats were found to be 11816 and 3907 iul, respectively table 1, while toxic doses of paracetamol 640 mgkg raised significantly the respective serum enzyme values to 10258 and 686219. Rats 150200 gm were divided into 5 groups containing 6 animals each. The body weights of wistar rats induced hepatotoxicityparacetamol compare to control. The aim was to investigate the hepatoprotective activity of ethanolic extract of the root of p. Antioxidative and protective actions of apigenin in a.
Paracetamolinduced experimental liver damage in case of paracetamolinduced hepatotoxicity, the rats were divided into 5 groups of 6 rats each. Protection against paracetamolinduced hepatotoxicity by. The mechanism underlying acetaminopheninduced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear dna fragmentation mitchell r. Pdf acetaminophen induced hepatotoxicity in wistar ratsa. The subjects were divided into 6 groups of 8 rats each. Materials and methods plant material fresh seeds of. Paracetamol overdose is a predominant cause of hepatotoxicity in both humans and experimental animals. Mar 17, 2006 the clinical characteristics of 51 children 6 males with paracetamol induced significant hepatotoxicity are shown in table 1 1 the median age was 14. N4hydroxyphenylethanamide, is the most commonly used antipyretic and pain reliever and since 1955 has been available overthecounter as a single formulation or in combination with other substances1. Rao2 1iftm university, lodhipur rajput, moradabad244002, uttar pradesh, india. Hepatotoxicity was induced in wistar male rats by oral administration, 2 gkg body weight on 7th day after the administration of ethanolic extract of trichosanthes lobata and silymarin 100 mgkg. Toxicology, 30 1984 297304 elsevier scientific publishers ireland ltd. Bio and phytochemical effect of amphora coffeaeformis.
To evaluate the hepatoprotective activity of aqueous extract of ziziphus jujuba leaves against paracetamolinduced liver injury in experimental rats. Druginduced liver injury is a cause of acute and chronic liver disease the liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. In this study, we investigated the protective effect of aqueous artichoke leaf extract ale against paracetamolinduced liver injury. Antioxidant activity of guaiazulene and protection against. The clinical characteristics of 51 children 6 males with paracetamol induced significant hepatotoxicity are shown in table 1 1 the median age was 14. Myristica fragrans kernels prevent paracetamolinduced. The hepatoprotective activity of conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice.
Ziziphus jujuba has been traditionally used in the ayurvedic system of medicine as a chief ingredient in many polyherbal formulations as antioxidant. Hepatotoxicity was established before the commencement of subsequent stages of the study. Hepatoprotective potential of ethanolic extract of. Paracetamol ester prodrug with lpyroglutamic acid pca, a biosynthetic precursor of glutathione, has been synthesized to reduce paracetamol hepatotoxicity and improve bioavailability. Pdf understanding the mechanism of chemical toxicity, which is essential for crossspecies and dose extrapolations, is a major challenge for.
Ginger zingiber officinale potentiate paracetamol induced chronic hepatotoxicity in rats article pdf available in journal of medicinal plant research 74. Rajesh kumar 2, shyam sundar gupta 2, satyawan singh 1, a. The rats were grouped into four with four rats in each group. Vehicle treated rats were kept on normal diet and served as control for 15 days. Group ii rats served as control and were administered with distilled water by oral administration of paracetamol pcm at a dose of 3 gkg body. Paracetamol pcm overdose induces hepatotoxicity in both humans and. Nov 01, 2012 acetaminophen apap overdose is the most common cause of acute liver failure in the west. In this study, we investigated the protective effect of aqueous artichoke leaf extract ale against paracetamol induced liver injury in rats using nacetylcysteine nac as a reference drug. Ginger zingiber officinale potentiate paracetamol induced.
Hepatoprotective and antioxidant activity of watercress extract on. Because it is both clinically relevant and experimentally convenient, apap intoxication. Evaluation of hepatoprotective effect of sesamum indicum. Evaluation of liver protective activity of moringa oleifera. Significant paracetamolinduced hepatotoxicity usually triggers nephrotoxicity. Renal insufficiency is reported to occur in 12% of patients exposed to. Significant paracetamol induced hepatotoxicity usually triggers nephrotoxicity. Two hours after the last slm dose, the mice were administered. Hepatoprotective activity against paracetamol induced hepatotoxicity animals were divided into seven groups n6 animals in each group. Paracetamol, hepatotoxicity, fatalities, liver toxicity. B 250 mgkg and 500 mgkg produced p in paracetamol induced liver marker enzymes and total bilirubin, but its 750 mgkg showed remarkable decline in alt, ast, alp and tb levels, compared to the reference. Jambilingappa, evaluation of hepatoprotective activity of aqueous extract of azadirachta indica neem leaves against paracetamol induced hepatotoxicity in albino rats, pharmacologyonline, vol. Therefore, the highest total antioxidant capacity and free radical scavenging activity were noticed with this extract. In order to evaluate the possible beneficial effects of slm, balbc mice were pretreated with slm 100 mgkg b.
Apigenin is known to have various pharmacological properties without causing significant toxicity. Sep 22, 2018 therefore, the highest total antioxidant capacity and free radical scavenging activity were noticed with this extract. Hepatoprotective activity of methanol extract of tecomella. The aim of our study was to investigate if the alterations in lipid peroxidation and antioxidant status are in favor to prove the efficacy of apigenin against paracetamol induced hepatotoxicity. Protective effect of artichoke leaf extract against. Results between 1992 and 2008, 663 patients were admitted with paracetamol. The rats in the lb group were administered a dose of 100 mgkg lb extract dissolved in saline via the intraperitoneal route for 7 days. Hepatoprotective activity of quercetin against paracetamolinduced. Hepatoprotective activities of methanol extract of hibiscus.
Several serum markers, aspartate transaminase, alanine. Hepatoprotective and antioxidant role of ziziphus jujuba. Hepatoprotective effect of hibiscus hispidissimus griffith. Evaluation of hepatoprotective effect of sesamum indicum linn. Effects of alliums sativum extract on paracetamol induced. Nacetylpaminophenol apap induced hepatotoxicity in rats, focusing on its antioxidant, antiinflammatory, and antiapoptotic activities. Protective effect of an ltype calcium channel blocker. To evaluate the hepatoprotective activity of aqueous extract of ziziphus jujuba leaves against paracetamol induced liver injury in experimental rats. Ethanolic extract of trichosanthes lobata was administered orally at doses of 200 mgkg and 400 mgkg body weight daily for 7 days. Original article lycium barbarum extract provides effective. Read antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats, journal of pharmacy and pharmacology. Acetaminophen or paracetamol apap overdose is a common cause of liver injury. A comparision of the effects of aloe barbadensis and allium. Pdf paracetamol hepatotoxicity in rats treated with crude.
Hepatotoxicity of paracetamol and related fatalities. Here, we report the hepatoprotective effect of ethanolic extract of sesamum indicum on paracetamolinduced liver damage in wistar rats. We observed statistically significant generation of reactive. To identify the clinical and biochemical risk factors associated with outcome of paracetamol induced significant hepatotoxicity in children. However, the risk of hepatotoxicity becomes substantial even at low dosages, such as 7. In mice, apap hepatotoxicity can be rapidly induced with a single dose. Research article hepatoprotective effect of plumbago zeylanica on paracetamol induced liver toxicity in rats n. Hepatic injury and subsequent hepatic failure due to both intentional and nonintentional overdose of acetaminophen apap has affected patients for decades, and involves the cornerstone metabolic pathways which take place in the microsomes within hepatocytes. The present study was aimed to find out the protective effect of quercetin on hepatotoxicity resulting by commonly used antimalarial drug chloroquine cq. Protective effect of rutin on paracetamol and ccl4induced. Silymarin prevents acetaminopheninduced hepatotoxicity in mice. The initial phases of toxicity were described in dr.
This is the reason why the present study was undertaken to evaluate the. A total of 32 rats were used for the study using extracts biochemical analysis. Group a was the control, group b received paracetamol over dose 500mg kg ml without extracts and group c. Nacetylpaminophenol apapinduced hepatotoxicity in rats, focusing on its antioxidant, anti. Acetaminophen induced hepatotoxicity in wistar ratsa proteomic approach. Research article hepatoprotective activities of astragalus. The aim of the study was to evaluate the protective effect of the aqueous extract of the fruiting bodies of a. Hepatoprotective effect of descurainia sophia seed extract against. Hepatoprotective activity of sphaeranthus amaranthoides whole plant in paracetamol induced hepatotoxicity in rats. Evaluation of hepatoprotective and antioxidant activity of. Acetaminophen apap overdose is the most common cause of acute liver failure in the west.
In the present study, overdose of paracetamol caused significant hepatic damage, which was observed through a substantial increase in the concentration of serum parameters. Liver toxicity was induced in spraguedawley rats by oral administration of 2gkg paracetamol on the 15th day after the administration of aqueous extract and silymarin. These findings indicated that acetaminophen was metabolically activated by cytochrome p450 enzymes to a reactive metabolite that depleted glutathione gsh and covalently bound to protein. Here, we report the hepatoprotective effect of ethanolic extract of sesamum indicum on paracetamol induced liver damage in wistar rats. Hepatoprotective activity of scindapsus officinalis fruit in paracetamol induced hepatotoxicity in rats nikhil shrivastava1, preeti agrawal 2, akanksha khare 3, sarlesh rajput 2, rajendra singh baghel 1, satyendra singh baghel 1 department of pharmacology toxicology research division 1, department of pharmaceutics 2, shriram. Pdf paracetamol induced hepatotoxicity researchgate. The role of cytochromep450 inhibitors in the prevention of. Meca against paracetamol induced liver damage in rats. Mill roots against paracetamol induced hepatotoxicity in rats arpita singh 1, g. Paracetamol, also known as acetaminophen, is the most commonly used antipyretic and pain reliever and since 1955 it is available overthecounter as a single formulation or in combination with other substances and, as indicated by the world health organization, it can be used in all the three steps of pain intensity. Hepatoprotective effect of caesalpinia crista against ccl4.
Acetaminophen induced hepatotoxicity is one of the most popular and widely used model for evaluating synthetic and natural compounds that are assumed to have hepatoprotective effects. India,2 research department of biochemistry, adhiparasakthi college of arts and science, kalavai, vellore district 632 506. Hepatoprotective effects of vitamin c and micronized vitamin. The aim of our study was to investigate if the alterations in lipid peroxidation and antioxidant status are in favor to prove the efficacy of apigenin against paracetamolinduced hepatotoxicity. Amelioration of paracetamolinduced hepatotoxicity in rat by the. Paracetamolinduced nephrotoxicity and oxidative stress in. Renal insufficiency is reported to occur in 12% of patients exposed to paracetamol toxicity prescott 1983. Consequently, efficiency of this algal extract was evaluated against hepatic intoxication induced by paracetamol in rats. Hepatotoxicity was induced in male wistar rat by pcm 2 gkg b. B 250 mgkg and 500 mgkg produced p hepatotoxicity in albino rats. Acetaminopheninduced liver injury in rats and mice.
Paracetamol hepatotoxicity in rats treated with crude extract of alpinia galanga. Protective effect of quercetin on chloroquineinduced. Silymarin slm is a hepatoprotective agent widely used for treating liver injury of different origin. Introduction paracetamol, also known as acetaminophen iupac name. Hepatoprotective effects of vitamin c and micronized vitamin c against paracetamol induced hepatotoxicity in rats. The toxicological studies of different paracetamol esters show that l5oxopyrrolidine2paracetamol carboxylate reduces toxicity after administration of an. Introduction paracetamol or acetaminophen apap is one of the most commonly used medications worldwide kaufman et al. No clear overdose pattern could be determined in 53 8. In this study, the hepatotoxicity of acetaminophen has been investigated in animal models of. Hepatotoxicity was induced in male wistar rat by pcm 2 gkg. Hence, the present experiment was aimed at studying the hepatoprotective effect of myristica fragrans nutmeg, kernel extract mfke in respect to paracetamol acetaminophen. Acute hepatotoxicity was induced by paracetamol 600 mgkg body weight administered once daily for one week whereas the extract of investigated plant was given orally throughout the whole.
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